The Biggest Mistakes People Make on GLP-1s

In this episode of Bioenergetics Beat, Heather Gray talks with Deniece Guyan about GLP-1 and GIP medications, the realities of metabolic health, and why so many people struggle with weight despite doing “all the right things.” The conversation covers how overtraining can work against you, why caloric deficits without proper support may contribute to muscle loss, and what personalized dosing looks like in a clinical setting.

Deniece shares her perspective from over five years of working with patients at a metabolic health clinic in Charleston, South Carolina. She addresses common misconceptions, including the idea that GLP-1 medications themselves cause muscle loss, and explains the role lifestyle factors like protein intake, resistance training, and fiber play in supporting results. Listeners will walk away with a clearer understanding of how to approach these tools safely and what questions to ask a qualified practitioner before getting started.

In This Episode, We Discuss:

• How overtraining and cortisol stacking may contribute to stubborn weight in midlife women
• The difference between GLP-1 and GIP pathways (semaglutide vs. tirzepatide)
• Why muscle loss during weight management is linked to lifestyle habits, not the medication itself
• Personalized dosing strategies and the importance of ongoing clinical monitoring
• Potential side effects including constipation, mood changes, and reduced motivation
• How GLP-1s may support blood sugar balance and a healthy inflammatory response

About Deniece Guyan:

Deniece Guyan (CPT, FDN-P) is a passionate advocate for holistic wellness and metabolic health who brings a wealth of knowledge and expertise to her work as a Functional Nutrition Practitioner. As a Certified Personal Trainer and Health Coach with over 28 years of experience, she focuses on hormonal balance and effective weight management strategies. Deniece is committed to empowering individuals to achieve a metabolic makeover through personalized nutrition, lifestyle modifications, and evidence-based interventions.

To learn more:

Website: http://mymetabolicmakeover.net

Instagram: @MetabolicMakeoverCHS

Clinic: Metabolic Medical Center, Charleston, SC