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Unlocking the Mystery of the MTHFR Gene and Lyme Disease

Have you ever wondered why some people appear to suffer from long-term Lyme disease, while others seem to be able to fight off the illness? The answer may lie in the MTHFR gene.

This blog post will discuss how a mutation of the MTHFR gene can potentially make you more susceptible to prolonged and severe symptoms related to Lyme disease.

Unlocking the mystery of this fascinating gene and its relationship to Lyme disease could help patients suffering from it find better treatments that work for them.

What Is the MTHFR Gene?

The MTHFR gene is responsible for encoding an enzyme that plays a crucial role in the regulation of folate metabolism. Folate metabolism is important because it helps the body convert certain types of vitamins and minerals into energy.

When the MTHFR gene is mutated, this can interfere with the body’s ability to produce enough folate, leading to a deficiency in folate-dependent enzymes. This can lead to an increased risk for a number of health issues, such as depression, heart disease, dementia, and even cancer.

How One Mutation Could Make Be Making Your Lyme Disease Worse

When the MTHFR gene has a mistake or mutation in it, it can change how our body produces folate. This can then lead to an accumulation of toxins in the body, which can create a toxic environment for bacteria that causes Lyme disease to flourish.

In addition, the MTHFR mutation may also make it more difficult for your body to fight off the infection properly. This means people with an MTHFR gene mutation may not be able to mount an effective immune response against the bacteria that cause Lyme disease. As a result, they are more likely to experience continued symptoms and a prolonged course of the illness.

Additionally, people with an MTHFR gene mutation may not be able to repair tissues as quickly, resulting in more severe and prolonged symptoms.

How to Test for an MTHFR Mutation

Genetic testing is available to determine if you have an MTHFR gene variant. There are versions of the gene test available for at-home use or at a doctor’s office. The test measures the level of amino acid homocysteine, which is an indicator of any issues with your MTHFR gene.

To be sure you are using a real MTHFR gene test, look for one that has been approved by a medical association, such as the American Pregnancy Association (APA). You can also have your primary medical provider order blood tests to determine if you have an MTHFR gene variant.

What Are Your Treatment Options?

If you have an MTHFR mutation and are struggling with the symptoms of Lyme disease, it’s essential to work with your healthcare provider to find a treatment plan that works for you. While Lyme disease can be a long-term ordeal for many patients, managing the symptoms and supporting your immune system can help you feel better and recover faster.

Here are some potential medical options for treating chronic Lyme disease symptoms made worse by an MTHFR gene variant:

1. Antibiotics

Antibiotics are a primary Lyme disease treatment and may be effective for people with an MTHFR mutation. However, they may need to be taken for a more extended period than individuals without a mutation.

Studies have shown that individuals with an MTHFR mutation may have a reduced response to antibiotics due to impaired immune function. Therefore, it’s crucial to work with a healthcare provider who can monitor your response to treatment and adjust your medications, if necessary.

2. Nutrient Support

People with an MTHFR mutation may have difficulty absorbing certain nutrients, such as folate. Taking supplements that contain active forms of folic acid, such as methylfolate, can help support your body’s immune function and promote tissue repair.

Taking supplements that include Omega-3 fatty acids can also help reduce the inflammation you may experience in connection with your infection.

3. Detoxification

MTHFR gene mutations can also affect your body’s ability to detoxify. Toxins can build up in the body over time, contributing to inflammation and immune dysfunction.

To support your body’s natural detoxification processes, you can try lifestyle changes such as avoiding alcohol, processed foods, and refined sugars (all of which can increase bodily inflammation).

You should also increase your intake of antioxidant-rich fruits and vegetables, especially green, leafy vegetables that are high in folate. And don’t forget to drink plenty of water!

4. Immune Support

Since an MTHFR genetic mutation may leave you struggling with a weakened immune system, you should support your immune system with supplements. These could range from vitamin C and vitamin D to zinc and probiotics that may be able to help your body fight off infections more effectively.

5. Reduce Stress

Chronic stress can negatively impact the immune system and worsen symptoms associated with Lyme disease.

To combat this, practice stress-management techniques, such as meditation or deep breathing exercises, to help reduce stress levels and improve overall health. You can also spend more time outdoors (such as taking a walk through nature) and practice other self-care techniques, such as taking a long bath with Epsom salts.

6. Addressing Co-Infections

Lyme disease often comes with other co-infections, such as Bartonella or Babesiosis. These co-infections can further weaken the immune system and increase inflammation on top of all the other symptoms you’re already dealing with.

Work with a Lyme-literate healthcare provider who can address these co-infections and has the required expertise to develop a treatment plan that addresses all of your unique health needs.


A variation in your body’s MTHFR gene can impact your response to Lyme disease due to its connection to folate, which plays a critical role in maintaining a healthy immune system. In order to alleviate your symptoms and enhance your overall well-being, consider implementing lifestyle interventions such as modifying your diet, engaging in detoxification practices, taking immune-boosting supplements, addressing co-infections, and reducing your stress levels.

Integrating FREmedica’s cutting-edge WAVE-1 frequency emitter into your daily routine can enhance your likelihood of recovering from the most severe effects of Lyme disease. This is true regardless of whether or not you have an MTHFR gene mutation.


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